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TREAT YOUR ELIGIBLE PATIENTS WITH FLEXIBILITY
Extend up to 6 month intervals* allowing stable patients to receive as few as 2 injections per year†


Patients could receive as few as 10 injections over 3 years as per the dosing schedules in the PULSAR and PHOTON trial protocols.
The frequency of monitoring visits should be based on the patient’s status and at the physician’s discretion.
Dosing diagram for illustrative purpose only.
*Following 3 monthly loading doses, intervals can be extended to Q16, dependent on visual and/or anatomic outcomes, and subsequently to 6 months (e.g. with a T&E regimen) if visual and/or anatomic outcomes are stable.
†Stable patients switching to EYLEA 8 mg do not require loading doses and can maintain or extend previous treatment intervals after the first injection of EYLEA. Consult the SmPC for full posology.
‡For patients who have previously been treated with EYLEA 2 mg or other anti-VEGF medicinal products and are switching to EYLEA 8 mg, the treatment regimen can differ from that used for treatment-naïve patients. Treatment intervals should be determined based on visual and/or anatomic outcomes: In patients with stable visual and anatomic outcomes, previous treatment intervals can be maintained or extended after the first injection of EYLEA 114.3 mg/mL, such as with a T&E dosing regimen; in patients with suboptimal visual and/or anatomic outcomes, treatment with EYLEA 8 mg may begin with 1 injection per month for up to 3 consecutive doses followed by adjustment of injection intervals, such as with a T&E dosing regimen.
EYLEA 114.3 mg/mL is indicated in adults for the treatment of neovascular (wet) age-related macular degeneration (nAMD) and visual impairment due to diabetic macular oedema (DMO).
Abbreviations
DMO, diabetic macular oedema. nAMD, neovascular (wet) age-related macular degeneration. Q16, every 16 weeks. Q24, every 24 weeks. SmPC, Summary of Product Characteristics. T&E, treat and extend. VEGF, vascular endothelial growth factor.
PP-EYL-GB-2900 | July 2025
- Referencesexpand_less
- 1EYLEA® 114.3 mg/mL Summary of Product Characteristics.
- 2Wong TY. Three-year outcomes of aflibercept 8 mg in nAMD: safety and efficacy results from the PULSAR extension study. Angiogenesis, Exudation, and Degeneration 2025. 8 February 2025. Virtual. Oral presentation.
- 3Do D. Aflibercept 8mg in DME: Key results from the PHOTON extension study. AAO. 18–21 October 2024. Chicago, USA. Oral presentation.
- 4Lanzetta P, et al. Intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (PULSAR): 48-week results from a randomised, double-masked, non-inferiority, phase 3 trial. Lancet. 2024;403(10432):1141–1152.
- 5Wykoff CC. Aflibercept 8 mg for diabetic macular edema: 96-week results from the Phase 2/3 PHOTON trial. EURETINA. 5–8 October 2023. Amsterdam, The Netherlands. Oral presentation.
- 6Brown DM, et al. Intravitreal aflibercept 8 mg in diabetic macular oedema (PHOTON): 48-week results from a randomised, double-masked, non-inferiority, phase 2/3 trial. Lancet. 2024;403(10432):1153–1163.
- 7Sivaprasad S, et al. BCVA gains with aflibercept 8 mg maintained through Week 96 in PULSAR with extended treatment intervals in patients with nAMD. ARVO. 5–9 May 2024. Seattle, USA. Oral presentation.